A Selectfluor-based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications

Kuhn J, Gradl S, Osterloh V, Gmeiner P, Hübner H, Heinrich M (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Article Number: e71318

Abstract

The classical Polonovski reaction starting from N-oxides of tertiary amines and acid chlorides, or anhydrides, offers manifold synthetic options. This large preparative potential is now broadened by a novel, unusual version of the Polonovski reaction based on Selectfluor and carboxylic acids, through which new chemical entities for synthetic and medicinal applications become readily accessible under particularly mild conditions.

Authors with CRIS profile

Jakob Kuhn Professur für Pharmazeutische Chemie Susanne Gradl Professur für Pharmazeutische Chemie Vanessa Osterloh Professur für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie Harald Hübner Lehrstuhl für Pharmazeutische Chemie Markus Heinrich Professur für Pharmazeutische Chemie

How to cite

APA:

Kuhn, J., Gradl, S., Osterloh, V., Gmeiner, P., Hübner, H., & Heinrich, M. (2026). A Selectfluor-based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications. Chemistry - A European Journal. https://doi.org/10.1002/chem.71318

MLA:

Kuhn, Jakob, et al. "A Selectfluor-based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications." Chemistry - A European Journal (2026).

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