Gene transfer mediated by α2-macroglobulin

Schneider H, Huse K, Birkenmeier G, Otto A, Scholz GH (1996)

Publication Type: Journal article, Original article

Publication year: 1996

Journal

Nucleic Acids Research Oxford University Press

Book Volume: 24

Pages Range: 3873-3874

Journal Issue: 19

DOI: 10.1093/nar/24.19.3873

Abstract

α2-Macroglobulin covalently linked to poly(L)-lysine can be used as a vehicle for receptor-mediated gene transfer. This modified α2-macroglobulin maintains its ability to bind to the α2-macroglobulin receptor, and was shown to introduce a luciferase reporter gene plasmid into HepG2 human hepatoma cells in vitro. The α2-macroglobulin receptor is a very large and multifunctional cell surface receptor, whose rapid and efficient internalization rate makes it attractive for gene therapy, e.g. for hepatic gene targeting via injection into the portal vein.

Authors with CRIS profile

Holm Schneider

Involved external institutions

Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut (FLI) DE Germany (DE) Universität Leipzig DE Germany (DE)

How to cite

APA:

Schneider, H., Huse, K., Birkenmeier, G., Otto, A., & Scholz, G.H. (1996). Gene transfer mediated by α2-macroglobulin. Nucleic Acids Research, 24(19), 3873-3874. https://doi.org/10.1093/nar/24.19.3873

MLA:

Schneider, Holm, et al. "Gene transfer mediated by α2-macroglobulin." Nucleic Acids Research 24.19 (1996): 3873-3874.

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