PDT dosimetry considerations for Endovascular PDT aimed at downstage Borderline Resectable pancreatic cancers
Lilge L, Vazquez AG, Saeidi T, Verde J, Wanert F, Spiridon IA, Schmid A, Swanstrom L, Bown S, Bogaards A (2025)
Publication Type: Conference contribution
Publication year: 2025
Journal
Publisher: SPIE
Book Volume: 13934
Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Event location: Munich, DEU
ISBN: 9781510698055
DOI: 10.1117/12.3097785
Abstract
Targeting pancreatic tumours immediately adjacent to major blood vessels aims to render patients suitable for standard surgical intervention to improve patient prognosis. Delivering the Photodynamic Therapy light endovascularly may achieve this goal, but it requires careful light and drug dosimetry. Building on reported pancreatic tumour and tissue response following interstitial BPD-mediated PDT, the tissues’ responsivities were determined and applied to in silico PDT dosimetry studies. Monte Carlo simulations were employed to determine the endovascular power delivery required to achieve necrotic radii of 5 to 15 mm beyond the arterial or venous wall as a function of the vessel lumen diameter. Pancreatic cancer necrosis up to 15mm deep is attainable adjacent to the blood vessel, albeit with limited selectivity to normal pancreatic tissues. Depending on the vessel’s location, simulations should include adjacent organs. Pre-PDT treatment simulations can assist in designing endovascular PDT to downgrade pancreatic cancer.
Authors with CRIS profile
Involved external institutions
University of Toronto
Canada (CA)
Institut de Chirurgie Guidée par l’Image de Strasbourg (IHU) / Institute of Image-Guided Surgery
France (FR)
University College London (UCL)
United Kingdom (GB)
Vascular Oncology Biotechnologies B.V.
Netherlands (NL)
Canada (CA)
Institut de Chirurgie Guidée par l’Image de Strasbourg (IHU) / Institute of Image-Guided Surgery
France (FR)
University College London (UCL)
United Kingdom (GB)
Vascular Oncology Biotechnologies B.V.
Netherlands (NL)
How to cite
APA:
Lilge, L., Vazquez, A.G., Saeidi, T., Verde, J., Wanert, F., Spiridon, I.A.,... Bogaards, A. (2025). PDT dosimetry considerations for Endovascular PDT aimed at downstage Borderline Resectable pancreatic cancers. In Zhiwei Huang, Lothar D. Lilge (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Munich, DEU: SPIE.
MLA:
Lilge, Lothar, et al. "PDT dosimetry considerations for Endovascular PDT aimed at downstage Borderline Resectable pancreatic cancers." Proceedings of the 4th Translational Biophotonics: Diagnostics and Therapeutics, Munich, DEU Ed. Zhiwei Huang, Lothar D. Lilge, SPIE, 2025.
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