Closed-Loop Molecular Communication with Local and Global Degradation: Modeling and ISI Analysis

Brand L, Vakilipoor Takaloo F, Botsch S, Jakumeit T, Lotter S, Schober R, Schäfer M (2025)

Publication Type: Conference contribution

Publication year: 2025

Publisher: Association for Computing Machinery

City/Town: New York City

Pages Range: 116-122

Conference Proceedings Title: NANOCOM '25: Proceedings of the 12th Annual ACM International Conference on Nanoscale Computing and Communication

Event location: Chengdu

DOI: 10.1145/3760544.3764144

Abstract

This paper presents a novel physics-based model for signal propagation in closed-loop molecular communication (MC) systems, which are particularly relevant for many envisioned biomedical applications, such as health monitoring or drug delivery within the closed-loop human cardiovascular system (CVS). Compared to open-loop systems, which are mostly considered in MC, closed-loop systems exhibit different characteristic effects influencing signaling molecule (SM) propagation. One key phenomenon are the periodic SM arrivals at the receiver (RX), leading to various types of inter-symbol interference (ISI) inherent to closed-loop system. To capture these characteristic effects, we propose an analytical model for the SM propagation inside closed-loop systems. The model accounts for arbitrary spatio-temporal SM release patterns at the transmitter (TX), and incorporates several environmental effects such as fluid flow, SM diffusion, and SM degradation. Moreover, to capture a wide range of practically relevant degradation and clearance mechanisms, the model includes both local removal (e.g., due to SM absorption into organs) and global removal (e.g., due to chemical degradation) of SMs. The accuracy of the proposed model is validated with three-dimensional (3-D) particle-based simulations (PBSs). Moreover, we utilize the proposed model to develop a rigorous characterization of the various types of ISI encountered in closed-loop MC systems.

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How to cite

APA:

Brand, L., Vakilipoor Takaloo, F., Botsch, S., Jakumeit, T., Lotter, S., Schober, R., & Schäfer, M. (2025). Closed-Loop Molecular Communication with Local and Global Degradation: Modeling and ISI Analysis. In NANOCOM '25: Proceedings of the 12th Annual ACM International Conference on Nanoscale Computing and Communication (pp. 116-122). Chengdu, CN: New York City: Association for Computing Machinery.

MLA:

Brand, Lukas, et al. "Closed-Loop Molecular Communication with Local and Global Degradation: Modeling and ISI Analysis." Proceedings of the NANOCOM '25: 12th Annual ACM International Conference on Nanoscale Computing and Communication, Chengdu New York City: Association for Computing Machinery, 2025. 116-122.

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