Bioactive glass (BG) particle shape affects the mechanical and biological properties of PLA/BG scaffolds for bone regeneration
Varlik E, Viviant L, Kurtuldu F, Nawaz Q, Chen S, Kraxner J, Galusek D, Michálek M, Boccaccini AR (2026)
Publication Type: Journal article
Publication year: 2026
Journal
Book Volume: 403
Article Number: 139383
DOI: 10.1016/j.matlet.2025.139383
Abstract
The impact of the addition of flame-spheroidized bioactive glass microspheres (BGMs) on the properties of poly(lactic acid) (PLA) composite filaments and scaffolds for bone regeneration is evaluated. Cube-shaped scaffolds were fabricated using fused deposition modeling. Scanning electron microscopy confirmed a uniform BGM distribution within the polymer matrix. PLA/BGM filaments demonstrated superior tensile strength to those containing irregularly-shaped particles. Scaffolds produced from PLA/BGM filaments exhibited enhanced compressive strength, achieving higher stress values at 30% strain. In-vitro studies with MG-63 cells revealed the highest cell viability of PLA/BGM scaffolds after seven days of incubation. These findings highlight the potential of BGMs to enhance mechanical and biological performance of PLA-based scaffolds, advancing their application in bone regeneration.
Authors with CRIS profile
Fatih Kurtuldu
Qaisar Nawaz Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Qaisar Nawaz Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
Trenčianska univerzita Alexandra Dubčeka v Trenčíne
Slovakia (SK)
École Nationale Supérieure de Céramique Industrielle (ENSCI)
France (FR)
Slovakia (SK)
École Nationale Supérieure de Céramique Industrielle (ENSCI)
France (FR)
How to cite
APA:
Varlik, E., Viviant, L., Kurtuldu, F., Nawaz, Q., Chen, S., Kraxner, J.,... Boccaccini, A.R. (2026). Bioactive glass (BG) particle shape affects the mechanical and biological properties of PLA/BG scaffolds for bone regeneration. Materials Letters, 403. https://doi.org/10.1016/j.matlet.2025.139383
MLA:
Varlik, Ertugrul, et al. "Bioactive glass (BG) particle shape affects the mechanical and biological properties of PLA/BG scaffolds for bone regeneration." Materials Letters 403 (2026).
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