The Biology of Dendritic Cells: In Health and Disease

Royzman D, Dörrie J, Heiß A, Sinner P, Peckert-Maier K, Schaft N, Sadeghi Shermeh A, Strack A, Wild A, Steinkasserer A (2025)

Publication Language: English

Publication Type: Book chapter / Article in edited volumes

Publication year: 2025

Journal

Advances in Experimental Medicine and Biology Kluwer Academic Publishers

Publisher: Springer

Edited Volumes: Innate Immunity: Pattern Recognition and Effector Mechanisms

Series: Advances in Experimental Medicine and Biology

City/Town: Cham

Book Volume: 1476

Pages Range: 1-30

ISBN: 978-3-031-85339-5

DOI: 10.1007/978-3-031-85340-1_1

Abstract

Dendritic cells (DCs) are crucial players within the immune system and are therefore abundant throughout the body. To achieve the variety of highly specialized DC subsets found in mammals, DC progenitor cells undergo a complex process of development and differentiation. The first divergence of different DC lineages occurs already during embryonic development, when Langerhans cells (LCs) are established by fetal liver hematopoiesis. Meanwhile, hematopoietic stem cells (HSCs) in the bone marrow give rise to DCs populating the blood and lymphoid organs. This chapter will provide an overview of both developmental pathways, distinguishing surface markers and key transcription factors.

Authors with CRIS profile

Dmytro Royzman Department of Immune Modulation Jan Dörrie Department of Dermatology Anita Heiß Department of Immune Modulation Pia Langguth Department of Immune Modulation Katrin Peckert-Maier Department of Immune Modulation Niels Schaft Department of Dermatology Atefeh Sadeghi Shermeh Department of Immune Modulation Astrid Strack Department of Immune Modulation Andreas Wild Department of Immune Modulation Alexander Steinkasserer Professur für Experimentelle Dermatologie

How to cite

APA:

Royzman, D., Dörrie, J., Heiß, A., Sinner, P., Peckert-Maier, K., Schaft, N.,... Steinkasserer, A. (2025). The Biology of Dendritic Cells: In Health and Disease. In Uday Kishore, Andrew J. T George (Eds.), Innate Immunity: Pattern Recognition and Effector Mechanisms. (pp. 1-30). Cham: Springer.

MLA:

Royzman, Dmytro, et al. "The Biology of Dendritic Cells: In Health and Disease." Innate Immunity: Pattern Recognition and Effector Mechanisms. Ed. Uday Kishore, Andrew J. T George, Cham: Springer, 2025. 1-30.

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