Hyams Grade and Ki-67 as Predictive Factors for Primary Treatment Failure in Olfactory Neuroblastoma

Koch M, Balk M, Schlaffer SM, Agaimy A, Iro H, Müller SK (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Abstract

Background/Objective: Tumor progression and first recurrence (TPR) after curative treatment for olfactory neuroblastoma can be regarded as primary treatment failure. Prognostic parameters for TPR and primary tumor-progression-free and recurrence-free survival (TPRFS) have not been sufficiently investigated in the literature. Methods: Data for 43 patients were analyzed retrospectively to evaluate prognostic parameters for TPR after curative treatment for olfactory neuroblastoma: age, age < / ≥ 50 years, sex, tumor classifications, curative therapy (monotherapy vs. combined, R0 vs. R1/2/x resection), Hyams-grade (grades, grade I–II/III–IV), and Ki-67 labeling index (values, labeling index < / ≥ 10%). The primary endpoints were TPR and TPRFS. Parameters that were significant after univariate analysis and Kaplan–Meier survival analysis were included in multiple regression and Cox regression analysis. Results: After univariate analysis, younger age (p = 0.032) and higher Ki-67 values (p = 0.001) were significantly negatively associated with time to the development of TPR. TPRFS according to Kaplan–Meier was significantly poorer with Hyams-grade III–IV (p = 0.002) and Ki-67 ≥ 10% (p = 0.001). After Cox regression analysis, TPRFS according to Kaplan–Meier was weekly significantly poorer for younger age (p = 0.033) and highly significantly worse for Hyams-grade III–IV (p = 0.005) and a Ki-67 LI ≥ 10% (p = 0.009). Tumor-stage classifications and all therapeutical parameters were not significantly associated with TPRFS. Conclusions: Out of a panel of parameters tested, younger age, Hyams-grade III–IV, and a Ki-67 LI ≥ 10% were significantly associated with a significantly worse TPRFS after multivariate Cox regression analysis. In particular, parameters such as Hyams-grade and the Ki-67 LI should be included in management considerations in olfactory neuroblastoma at an early stage. Level of Evidence: 3.

Authors with CRIS profile

Michael Koch Medizinische Fakultät Matthias Balk Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Sven-Martin Schlaffer Department of Neurosurgery Abbas Agaimy Institute of Pathology Heinrich Iro Lehrstuhl für Hals-Nasen-Ohrenheilkunde Sarina Katrin Ursel Müller-Hübner Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik)

How to cite

APA:

Koch, M., Balk, M., Schlaffer, S.-M., Agaimy, A., Iro, H., & Müller, S.K. (2025). Hyams Grade and Ki-67 as Predictive Factors for Primary Treatment Failure in Olfactory Neuroblastoma. Laryngoscope. https://doi.org/10.1002/lary.32238

MLA:

Koch, Michael, et al. "Hyams Grade and Ki-67 as Predictive Factors for Primary Treatment Failure in Olfactory Neuroblastoma." Laryngoscope (2025).

BibTeX: Download