B-cell depletion in autoimmune diseases.
Schett G, Nagy G, Krönke G, Mielenz D (2024)
Publication Type: Journal article, Review article
Publication year: 2024
Journal
Book Volume: 83
Pages Range: 1409-1420
Journal Issue: 11
Abstract
B cells have a pivotal function in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. In autoimmune disease, B cells orchestrate antigen presentation, cytokine production and autoantibody production, the latter via their differentiation into antibody-secreting plasmablasts and plasma cells. This article addresses the current therapeutic strategies to deplete B cells in order to ameliorate or potentially even cure autoimmune disease. It addresses the main target antigens in the B-cell lineage that are used for therapeutic approaches. Furthermore, it summarises the current evidence for successful treatment of autoimmune disease with monoclonal antibodies targeting B cells and the limitations and challenges of these approaches. Finally, the concept of deep B-cell depletion and immunological reset by chimeric antigen receptor T cells is discussed, as well as the lessons from this approach for better understanding the role of B cells in autoimmune disease.
Authors with CRIS profile
Georg Schett
Lehrstuhl für Innere Medizin III
Gerhard Krönke
Department of Medicine 3 – Rheumatology and Immunology
Dirk Mielenz
Medizinische Fakultät
Involved external institutions
Hungary (HU)How to cite
APA:
Schett, G., Nagy, G., Krönke, G., & Mielenz, D. (2024). B-cell depletion in autoimmune diseases. Annals of the Rheumatic Diseases, 83(11), 1409-1420. https://doi.org/10.1136/ard-2024-225727
MLA:
Schett, Georg, et al. "B-cell depletion in autoimmune diseases." Annals of the Rheumatic Diseases 83.11 (2024): 1409-1420.
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