Investigation of Inertial Cavitation of Sonosensitive and Biocompatible Nanoparticles in Flow - Through Tissue- Mimicking Phantoms Employing Focused Ultrasound
George B, Savsek U, Fischer D, Ermert H, Rupitsch SJ (2021)
Publication Language: English
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 7
Pages Range: 163-166
Journal Issue: 2
Abstract
A promising approach to drug delivery applications for chemotherapeutics is the use of drug carriers to reduce the total amount of cytostatics, minimizing side effects. In addition, the carriers, loaded with the drug, can be guided to the tumorous tissue via the vascular system, which enables a local drug release (LDR). In our case, LDR is activated due to the sonosensitive behavior of the nanocapsules by inertial cavitation (IC) caused by focused ultrasound (FUS). Thereby, IC is excited by employing sound pressures within the recommended limit allowed for diagnostic ultrasound. In order to verify this drug delivery approach for its clinical suitability, a tissue-mimicking flow -through phantom, containing a small vessel, is used. Investigations have shown that the drug releasing cavitation effect associated with the sonosensitive and biocompatible nanocapsules also occurs in fine vessel structures, even in the case of moving particles and vessel diameters dc smaller than the wavelength λ.
Authors with CRIS profile
Ula Savsek
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie
Dagmar Fischer
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie
Helmut Ermert
Professur für Nanomedizin
Involved external institutions
Germany (DE)How to cite
APA:
George, B., Savsek, U., Fischer, D., Ermert, H., & Rupitsch, S.J. (2021). Investigation of Inertial Cavitation of Sonosensitive and Biocompatible Nanoparticles in Flow - Through Tissue- Mimicking Phantoms Employing Focused Ultrasound. Current Directions in Biomedical Engineering, 7(2), 163-166. https://doi.org/10.1515/cdbme-2021-2042
MLA:
George, Benedikt, et al. "Investigation of Inertial Cavitation of Sonosensitive and Biocompatible Nanoparticles in Flow - Through Tissue- Mimicking Phantoms Employing Focused Ultrasound." Current Directions in Biomedical Engineering 7.2 (2021): 163-166.
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