Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia

Pradhan R, Dieterich W, Natarajan A, Schwappacher R, Reljic D, Herrmann HJ, Neurath M, Zopf Y (2024)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2024

Journal

Cancers MDPI

Book Volume: 16

Article Number: 1921

Journal Issue: 10

DOI: 10.3390/cancers16101921

Abstract

Cancer cachexia is a multifaceted syndrome that impacts individuals with advanced cancer. It causes numerous pathological changes in cancer patients, such as inflammation and metabolic dysfunction, which further diminish their quality of life. Unfortunately, cancer cachexia also increases the risk of mortality in affected individuals, making it an important area of focus for cancer research and treatment. Several potential nutritional therapies are being tested in preclinical and clinical models for their efficacy in improving muscle metabolism in cancer patients. Despite promising results, no special nutritional therapies have yet been validated in clinical practice. Multiple studies provide evidence of the benefits of increasing muscle protein synthesis through an increased intake of amino acids or protein. There is also increasing evidence that exercise can reduce muscle atrophy by modulating protein synthesis. Therefore, the combination of protein intake and exercise may be more effective in improving cancer cachexia. This review provides an overview of the preclinical and clinical approaches for the use of amino acids with and without exercise therapy to improve muscle metabolism in cachexia.

Authors with CRIS profile

Rashmita Pradhan Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Walburga Dieterich Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Anirudh Natarajan Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Dejan Reljic Stiftungsprofessur für Experimentelle Ernährungs- und Sportmedizin Markus Neurath Lehrstuhl für Innere Medizin I (Medizin 1) Yurdagül Zopf Professur für Integrative Medizin mit dem Schwerpunkt Ernährungsmedizin (Stiftungsprofessur der Hector Stiftung II gGmbH)

How to cite

APA:

Pradhan, R., Dieterich, W., Natarajan, A., Schwappacher, R., Reljic, D., Herrmann, H.J.,... Zopf, Y. (2024). Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia. Cancers, 16(10). https://doi.org/10.3390/cancers16101921

MLA:

Pradhan, Rashmita, et al. "Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia." Cancers 16.10 (2024).

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