Membrane Fluctuation Model for Understanding the Effect of Receptor Nanoclustering on the Activation of Natural Killer Cells through Biomechanical Feedback

Pandey A, Nowakowski P, Ureña Martin C, Abu Ahmad M, Edri A, Toledo E, Tzadka S, Walther J, Le Saux G, Porgador A, Smith AS, Schvartzman M (2024)


Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 24

Pages Range: 5395-5402

Journal Issue: 18

DOI: 10.1021/acs.nanolett.3c02815

Abstract

We investigated the role of ligand clustering and density in the activation of natural killer (NK) cells. To that end, we designed reductionist arrays of nanopatterned ligands arranged with different cluster geometries and densities and probed their effects on NK cell activation. We used these arrays as an artificial microenvironment for the stimulation of NK cells and studied the effect of the array geometry on the NK cell immune response. We found that ligand density significantly regulated NK cell activation while ligand clustering had an impact only at a specific density threshold. We also rationalized these findings by introducing a theoretical membrane fluctuation model that considers biomechanical feedback between ligand-receptor bonds and the cell membrane. These findings provide important insight into NK cell mechanobiology, which is fundamentally important and essential for designing immunotherapeutic strategies targeting cancer.

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APA:

Pandey, A., Nowakowski, P., Ureña Martin, C., Abu Ahmad, M., Edri, A., Toledo, E.,... Schvartzman, M. (2024). Membrane Fluctuation Model for Understanding the Effect of Receptor Nanoclustering on the Activation of Natural Killer Cells through Biomechanical Feedback. Nano Letters, 24(18), 5395-5402. https://doi.org/10.1021/acs.nanolett.3c02815

MLA:

Pandey, Ashish, et al. "Membrane Fluctuation Model for Understanding the Effect of Receptor Nanoclustering on the Activation of Natural Killer Cells through Biomechanical Feedback." Nano Letters 24.18 (2024): 5395-5402.

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