Label-free quantitative phase imaging-based assessment of intestinal inflammation in patients with ulcerative colitis

Bokemeyer A, Buskermolen J, Ketelhut S, Tepasse PR, Vollenberg R, Trebicka J, Schmidt HH, Vieth M, Bettenworth D, Kemper B (2024)

Publication Type: Conference contribution

Publication year: 2024

Journal

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Publisher: SPIE

Book Volume: 12852

Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Event location: San Francisco, CA, USA

ISBN: 9781510669635

DOI: 10.1117/12.3002347

Abstract

We evaluated the application of quantitative phase imaging (QPI) with digital holographic microscopy (DHM) for the assessment of histopathological inflammation in patients with Ulcerative colitis (UC). Endoscopically obtained colonic and rectal mucosal biopsy samples from 21 patients with UC were analyzed by capturing DHM QPI images from which subsequently the subepithelial refractive index (RI) was determined. The retrieved RI data were correlated with established histological scoring systems including the Nancy index (NI) as well as with endoscopic and clinical findings. In conclusion, our data demonstrate DHM as a promising tool for quantitative assessment of mucosal inflammation in patients with UC.

Authors with CRIS profile

Michael Vieth Medizinische Fakultät

Involved external institutions

Universitätsklinikum Essen DE Germany (DE) Universitätsklinikum Münster DE Germany (DE) Westfälische Wilhelms-Universität (WWU) Münster DE Germany (DE)

How to cite

APA:

Bokemeyer, A., Buskermolen, J., Ketelhut, S., Tepasse, P.R., Vollenberg, R., Trebicka, J.,... Kemper, B. (2024). Label-free quantitative phase imaging-based assessment of intestinal inflammation in patients with ulcerative colitis. In Yang Liu, YongKeun Park (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. San Francisco, CA, USA: SPIE.

MLA:

Bokemeyer, A., et al. "Label-free quantitative phase imaging-based assessment of intestinal inflammation in patients with ulcerative colitis." Proceedings of the Quantitative Phase Imaging X 2024, San Francisco, CA, USA Ed. Yang Liu, YongKeun Park, SPIE, 2024.

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