The population context is a driver of the heterogeneous response of epithelial cells to interferons
Metz-Zumaran C, Uckeley ZM, Doldan P, Muraca F, Keser Y, Lukas P, Kuropka B, Küchenhoff L, Rastgou Talemi S, Höfer T, Freund C, Cavalcanti-Adam EA, Graw F, Stanifer M, Boulant S (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 20
Pages Range: 242-275
Journal Issue: 3
DOI: 10.1038/s44320-024-00011-2
Abstract
(Figure presented.) The heterogeneous response to interferons in epithelial cells is determined by the population context (i.e. a cell’s positions within a population) through cell polarization and basolateral localization of the interferon receptor. Isogenic epithelial cells respond in a heterogeneous manner to type I and type III interferons. The population context (position of a cell within a population) drives the heterogeneous response to interferons, with cells located at the edge of a population being more responsive than cells located in the center of a population. Cells in the center of a population are refractive to interferon treatment from their apical side due to the polarized basolateral distribution of the interferon receptors. By controlling the response to interferon treatment, the population context affects susceptibility to viral infection.
Authors with CRIS profile
Involved external institutions
University of Florida
United States (USA) (US)
Universitätsklinikum Heidelberg
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Freie Universität Berlin
Germany (DE)
Veterans Affairs Healthcare System Boston and Harvard Medical School
United States (USA) (US)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
Max-Planck-Institut für medizinische Forschung / Max Planck Institute for Medical Research
Germany (DE)
United States (USA) (US)
Universitätsklinikum Heidelberg
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Freie Universität Berlin
Germany (DE)
Veterans Affairs Healthcare System Boston and Harvard Medical School
United States (USA) (US)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
Max-Planck-Institut für medizinische Forschung / Max Planck Institute for Medical Research
Germany (DE)
How to cite
APA:
Metz-Zumaran, C., Uckeley, Z.M., Doldan, P., Muraca, F., Keser, Y., Lukas, P.,... Boulant, S. (2024). The population context is a driver of the heterogeneous response of epithelial cells to interferons. Molecular Systems Biology, 20(3), 242-275. https://doi.org/10.1038/s44320-024-00011-2
MLA:
Metz-Zumaran, Camila, et al. "The population context is a driver of the heterogeneous response of epithelial cells to interferons." Molecular Systems Biology 20.3 (2024): 242-275.
BibTeX: Download