“Photo-Adrenalines”: Photoswitchable β2-Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling
Sink A, Gerwe H, Hübner H, Boivin-Jahns V, Fender J, Lorenz K, Gmeiner P, Decker M (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Abstract
β2-adrenergic receptor (β2-AR) agonists are used for the treatment of asthma and chronic obstructive pulmonary disease, but also play a role in other complex disorders including cancer, diabetes and heart diseases. As the cellular and molecular mechanisms in various cells and tissues of the β2-AR remain vastly elusive, we developed tools for this investigation with high temporal and spatial resolution. Several photoswitchable β2-AR agonists with nanomolar activity were synthesized. The most potent agonist for β2-AR with reasonable switching is a one-digit nanomolar active, trans-on arylazopyrazole-based adrenaline derivative and comprises valuable photopharmacological properties for further biological studies with high structural accordance to the native ligand adrenaline.
Authors with CRIS profile
Harald Hübner
Lehrstuhl für Pharmazeutische Chemie
Peter Gmeiner
Lehrstuhl für Pharmazeutische Chemie
Additional Organisation(s)
Involved external institutions
Germany (DE)How to cite
APA:
Sink, A., Gerwe, H., Hübner, H., Boivin-Jahns, V., Fender, J., Lorenz, K.,... Decker, M. (2024). “Photo-Adrenalines”: Photoswitchable β2-Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling. Chemistry - A European Journal. https://doi.org/10.1002/chem.202303506
MLA:
Sink, Alexandra, et al. "“Photo-Adrenalines”: Photoswitchable β2-Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling." Chemistry - A European Journal (2024).
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