Eckenberger E, Raczka T, Neuhuber W, Distel L, Klein S (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 6
Pages Range: 3089-3102
Journal Issue: 8
Mesoporous and nonmesoporous SiO2@MnFe2O4 nanostructures were loaded with the hypoxia-inducible factor-1 inhibitor acriflavine for combined radiation and hypoxia therapies. The X-ray irradiation of the drug-loaded nanostructures not only triggered the release of the acriflavine inside the cells but also initiated an energy transfer from the nanostructures to surface-adsorbed oxygen to generate singlet oxygen. While the drug-loaded mesoporous nanostructures showed an initial drug release before the irradiation, the drug was primarily released upon X-ray radiation in the case of the nonmesoporous nanostructures. However, the drug loading capacity was less efficient for the nonmesoporous nanostructures. Both drug-loaded nanostructures proved to be very efficient in irradiated MCF-7 multicellular tumor spheroids. The damage of these nanostructures toward the nontumorigenic MCF-10A multicellular spheroids was very limited because of the small number of nanostructures that entered the MCF-10A spheroids, while similar concentrations of acriflavine without nanostructures were toxic for the MCF-10A spheroids.
APA:
Eckenberger, E., Raczka, T., Neuhuber, W., Distel, L., & Klein, S. (2023). Acriflavine-Functionalized Silica@Manganese Ferrite Nanostructures for Synergistic Radiation and Hypoxia Therapies. ACS Applied Bio Materials, 6(8), 3089-3102. https://dx.doi.org/10.1021/acsabm.2c01021
MLA:
Eckenberger, Elisabeth, et al. "Acriflavine-Functionalized Silica@Manganese Ferrite Nanostructures for Synergistic Radiation and Hypoxia Therapies." ACS Applied Bio Materials 6.8 (2023): 3089-3102.
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