Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis

Sinner P, Peckert-Maier K, Mohammadian H, Kuhnt C, Draßner C, Panagiotakopoulou V, Rauber S, Linnerbauer M, Haimon Z, Royzman D, Kronenberg-Versteeg D, Ramming A, Steinkasserer A, Wild A (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Nature Communications Nature Publishing Group: Nature Communications

Book Volume: 14

Article Number: 4601

Journal Issue: 1

DOI: 10.1038/s41467-023-40370-2

Abstract

Microglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue, and the initial response of microglia determines the severity of neuro-inflammatory diseases. The CD83 molecule has been recently shown to modulate the activation status of dendritic cells and macrophages. Although the expression of CD83 is associated with early microglia activation in various disease settings, its functional relevance for microglial biology has been elusive. Here, we describe a thorough assessment of CD83 regulation in microglia and show that CD83 expression in murine microglia is not only associated with cellular activation but also with pro-resolving functions. Using single-cell RNA-sequencing, we reveal that conditional deletion of CD83 results in an over-activated state during neuroinflammation in the experimental autoimmune encephalomyelitis model. Subsequently, CD83-deficient microglia recruit more pathogenic immune cells to the central nervous system, deteriorating resolving mechanisms and exacerbating the disease. Thus, CD83 in murine microglia orchestrates cellular activation and, consequently, also the resolution of neuroinflammation.

Authors with CRIS profile

Hashem Mohammadian Department of Medicine 3 – Rheumatology and Immunology Simon Rauber Department of Medicine 3 – Rheumatology and Immunology Mathias Linnerbauer Department of Neurology Dmytro Royzman Department of Immune Modulation Andreas Ramming Professur für Immunologie der Organschädigung Alexander Steinkasserer Professur für Experimentelle Dermatologie Andreas Wild Department of Immune Modulation

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

A089: CD83 as a key regulator during immune homeostasis and neuroinflammation July 1, 2020 - June 30, 2023

Involved external institutions

Hertie-Institut für klinische Hirnforschung DE Germany (DE) Weizmann Institute of Science IL Israel (IL)

How to cite

APA:

Sinner, P., Peckert-Maier, K., Mohammadian, H., Kuhnt, C., Draßner, C., Panagiotakopoulou, V.,... Wild, A. (2023). Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40370-2

MLA:

Sinner, Pia, et al. "Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis." Nature Communications 14.1 (2023).

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