Tuning the Polarity of Antibiotic-Cy5 Conjugates Enables Highly Selective Labeling of Binding Sites

Graßl F, Konrad M, Krüll J, Pezerovic A, Zähnle L, Burkovski A, Heinrich M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

DOI: 10.1002/chem.202301208

Abstract

Multidrug-resistant bacteria pose a major threat to global health, even as newly introduced antibiotics continue to lose their therapeutic value. Against this background, deeper insights into bacterial interaction with antibiotic drugs are urgently required, whereas fluorescently labeled drug conjugates can serve as highly valuable tools. Herein, the preparation and biological evaluation of 13 new fluorescent antibiotic-Cy5 dye conjugates is described, in which the tuning of the polarity of the Cy5 dye proved to be a key element to achieve highly favorable properties for various fields of application.

Authors with CRIS profile

Fabian Graßl Professur für Pharmazeutische Chemie Maike Konrad Professur für Mikrobiologie Jasmin Krüll Lehrstuhl für Pharmazeutische Chemie Azra Pezerovic Lehrstuhl für Pharmazeutische Chemie Leon Zähnle Lehrstuhl für Pharmazeutische Chemie Andreas Burkovski Professur für Mikrobiologie Markus Heinrich Professur für Pharmazeutische Chemie

How to cite

APA:

Graßl, F., Konrad, M., Krüll, J., Pezerovic, A., Zähnle, L., Burkovski, A., & Heinrich, M. (2023). Tuning the Polarity of Antibiotic-Cy5 Conjugates Enables Highly Selective Labeling of Binding Sites. Chemistry - A European Journal. https://dx.doi.org/10.1002/chem.202301208

MLA:

Graßl, Fabian, et al. "Tuning the Polarity of Antibiotic-Cy5 Conjugates Enables Highly Selective Labeling of Binding Sites." Chemistry - A European Journal (2023).

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