Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract

Paulus LP, Bühler A, Wagner A, Raming R, Jüngert J, Simon D, Tascilar K, Schnell A, Rother U, Eckstein M, Lang W, Hörning A, Schett G, Neurath M, Waldner M, Trollmann R, Wölfle J, Bohndiek SE, Regensburger A, Knieling F (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Advanced Science Wiley Open Access

DOI: 10.1002/advs.202302562

Abstract

Real-time imaging and functional assessment of the intestinal tract and its transit pose a significant challenge to conventional clinical diagnostic methods. Multispectral optoacoustic tomography (MSOT), a molecular-sensitive imaging technology, offers the potential to visualize endogenous and exogenous chromophores in deep tissue. Herein, a novel approach using the orally administered clinical-approved fluorescent dye indocyanine green (ICG) for bedside, non-ionizing evaluation of gastrointestinal passage is presented. The authors are able to show the detectability and stability of ICG in phantom experiments. Furthermore, ten healthy subjects underwent MSOT imaging at multiple time points over eight hours after ingestion of a standardized meal with and without ICG. ICG signals can be visualized and quantified in different intestinal segments, while its excretion is confirmed by fluorescent imaging of stool samples. These findings indicate that contrast-enhanced MSOT (CE-MSOT) provides a translatable real-time imaging approach for functional assessment of the gastrointestinal tract.

Authors with CRIS profile

Lars-Philip Paulus Lehrstuhl für Kinder- und Jugendmedizin Alexandra Wagner Professur für Kinder- u. Jugendmedizin Schwerpunkt Neuropädiatrie Roman Raming Department of Paediatrics and Adolescent Medicine Jörg Jüngert Medizinische Fakultät David Simon Lehrstuhl für Innere Medizin III Koray Tascilar Department of Medicine 3 – Rheumatology and Immunology Alexander Schnell Department of Paediatrics and Adolescent Medicine Ulrich Rother Department of Vascular Surgery Markus Eckstein Institute of Pathology Werner Lang Department of Vascular Surgery André Hörning Department of Paediatrics and Adolescent Medicine Georg Schett Lehrstuhl für Innere Medizin III Markus Neurath Lehrstuhl für Innere Medizin I Maximilian Waldner Professur für Funktionelle Bildgebung in der Medizin Regina Trollmann Medizinische Fakultät Joachim Wölfle Lehrstuhl für Kinder- und Jugendmedizin Adrian Regensburger Department of Paediatrics and Adolescent Medicine Ferdinand Knieling Department of Paediatrics and Adolescent Medicine

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

J089: Multispectral optoacoustic tomography for non invasive characterization of strictures in Crohn’s disease Jan. 1, 2021 - March 31, 2024

Involved external institutions

University of Cambridge GB United Kingdom (GB)

How to cite

APA:

Paulus, L.-P., Bühler, A., Wagner, A., Raming, R., Jüngert, J., Simon, D.,... Knieling, F. (2023). Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract. Advanced Science. https://doi.org/10.1002/advs.202302562

MLA:

Paulus, Lars-Philip, et al. "Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract." Advanced Science (2023).

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