The FRESH Study: Treatment of Intracranial Aneurysms with the New FRED X Flow Diverter with Antithrombotic Surface Treatment Technology-First Multicenter Experience in 161 Patients

Vollherbst DF, Lücking H, Duplessis J, Sonnberger M, Maurer C, Kocer N, Killer-Oberpfalzer M, Rautio R, Valvassori L, Berlis A, Gasser S, Gatt S, Dörfler A, Bendszus M, Moehlenbruch MA (2023)

Publication Type: Journal article

Publication year: 2023

Journal

American Journal of Neuroradiology American Society of Neuroradiology

Book Volume: 44

Pages Range: 474-480

Journal Issue: 4

DOI: 10.3174/ajnr.A7834

Abstract

BACKGROUND AND PURPOSE: Flow diverters with antithrombotic coatings are increasingly used to improve the safety of flow diverter treatments of intracranial aneurysms. This study aimed to investigate the safety and short-term efficacy of the new FRED X flow diverter. MATERIALS AND METHODS: Medical charts and procedural and imaging data of a consecutive series of patients with intracranial aneurysms who were treated with the FRED X at 9 international neurovascular centers were retrospectively analyzed. RESULTS: One hundred sixty-one patients (77.6% women; mean age, 55 years) with 184 aneurysms (11.2% acutely ruptured) were included in this study. Most aneurysms were located in the anterior circulation (77.0%), most frequently at the ICA (72.7%). The FRED X was successfully implanted in all procedures. Additional coiling was performed in 29.8%. In-stent balloon angioplasty was necessary in 2.5%. The rate of major adverse events was 3.1%. Thrombotic events occurred in 7 patients (4.3%) with 4 intra- and 4 postprocedural in-stent thromboses, respectively (1 patient had both peri- and postprocedural thrombosis). Of these thrombotic events, only 2 (1.2%) led to major adverse events (ischemic strokes). Postinterventional neurologic morbidity and mortality were observed in 1.9% and 1.2%, respectively. The rate of complete aneurysm occlusion after a mean follow-up of 7.0 months was 66.0%. CONCLUSIONS: The new FRED X is a safe and feasible device for aneurysm treatment. In this retrospective multicenter study, the rate of thrombotic complications was low, and the short-term occlusion rates are satisfactory.

Authors with CRIS profile

Hannes Lücking Department of Neuroradiology Arnd Dörfler Department of Neuroradiology

Involved external institutions

Universitätsklinikum Heidelberg DE Germany (DE) Royal Infirmary of Edinburgh NHS Trust GB United Kingdom (GB) Johannes Kepler Universität (JKU) Linz AT Austria (AT) Universitätsklinikum Augsburg DE Germany (DE) Istanbul University Cerrahpaşa / İstanbul Üniversitesi Cerrahpaşa (IUC) TR Turkey (TR) Paracelsus Medizinische Privatuniversität, Nürnberg DE Germany (DE) Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS) FI Finland (FI) Ospedale San Carlo Borromeo IT Italy (IT)

How to cite

APA:

Vollherbst, D.F., Lücking, H., Duplessis, J., Sonnberger, M., Maurer, C., Kocer, N.,... Moehlenbruch, M.A. (2023). The FRESH Study: Treatment of Intracranial Aneurysms with the New FRED X Flow Diverter with Antithrombotic Surface Treatment Technology-First Multicenter Experience in 161 Patients. American Journal of Neuroradiology, 44(4), 474-480. https://dx.doi.org/10.3174/ajnr.A7834

MLA:

Vollherbst, D. F., et al. "The FRESH Study: Treatment of Intracranial Aneurysms with the New FRED X Flow Diverter with Antithrombotic Surface Treatment Technology-First Multicenter Experience in 161 Patients." American Journal of Neuroradiology 44.4 (2023): 474-480.

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