Hahn AM, Vogg L, Brey S, Schneider A, Schäfer S, Palmisano R, Pavlova A, Sandrock I, Tan L, Fichtner AS, Prinz I, Ravens S, Winkler T (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 42
Pages Range: 112558
Article Number: 112253
Journal Issue: 3
DOI: 10.1016/j.celrep.2023.112253
The clonal selection theory describes key features of adaptive immune responses of B and T cells. For αβ T cells and B cells, antigen recognition and selection principles are known at a detailed molecular level. The precise role of the antigen receptor in γδ T cells remains less well understood. To better understand the role of the γδ T cell receptor (TCR), we generate an orthotopic TCRδ transgenic mouse model. We demonstrate a multi-layered functionality of γδ TCRs and diverse roles of CDR3δ-mediated selection during γδ T cell development. Whereas epithelial populations using Vγ5 or Vγ7 chains are almost unaffected in their biology in the presence of the transgenic TCRδ chain, pairing with Vγ1 positively selects γδ T cell subpopulations with distinct programs in several organs, thereby distorting the repertoire. In conclusion, our data support dictation of developmental tropism together with adaptive-like recognition principles in a single antigen receptor.
APA:
Hahn, A.M., Vogg, L., Brey, S., Schneider, A., Schäfer, S., Palmisano, R.,... Winkler, T. (2023). A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages. Cell Reports, 42(3), 112558. https://doi.org/10.1016/j.celrep.2023.112253
MLA:
Hahn, Anne Maria, et al. "A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages." Cell Reports 42.3 (2023): 112558.
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