Application of a three-fluid nozzle for the preparation of amorphous solid dispersions

Corell C, Seyferth S, Fischer D, Schiffter HA (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Drying Technology Taylor & Francis

DOI: 10.1080/07373937.2023.2177308

Abstract

In this work, the manufacture of amorphous solid dispersions of poorly water-soluble carbamazepine using a laboratory spray drying setup with a three-fluid nozzle and two separate liquid feed solutions of (a) the active and (b) the polymeric excipient (copovidone or basic butylated methacrylate copolymer) was investigated and compared to a traditional two-fluid nozzle setup. Results show that particles with the desired drug content were manufactured using the three-fluid nozzle setup. Amorphous solid dispersion could be obtained up to a drug load of 50% (w/w) processing solutions with miscible solvents and copovidone as polymer. Higher active concentrations, the use of immiscible solvents or switching of the capillaries led to a substantial crystallization of carbamazepine as seen in XRD and DSC analysis. The polymorphic form IV of carbamazepine was formed in the presence of copovidone at high solid concentrations of the liquid feed.

Authors with CRIS profile

Carolina Corell Lehrstuhl für Pharmazeutische Technologie und Biopharmazie Stefan Seyferth Lehrstuhl für Pharmazeutische Technologie und Biopharmazie Dagmar Fischer Lehrstuhl für Pharmazeutische Technologie und Biopharmazie

Involved external institutions

TH Köln / Technische Hochschule Köln / Fachhochschule Köln DE Germany (DE)

How to cite

APA:

Corell, C., Seyferth, S., Fischer, D., & Schiffter, H.A. (2023). Application of a three-fluid nozzle for the preparation of amorphous solid dispersions. Drying Technology. https://dx.doi.org/10.1080/07373937.2023.2177308

MLA:

Corell, Carolina, et al. "Application of a three-fluid nozzle for the preparation of amorphous solid dispersions." Drying Technology (2023).

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