Paulus LP, Wagner A, Buehler A, Raming R, Jüngert J, Simon D, Tascilar K, Schnell A, Günther J, Rother U, Lang W, Hörning A, Schett G, Neurath M, Wölfle J, Waldner M, Knieling F, Regensburger A (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 30
Article Number: 100457
DOI: 10.1016/j.pacs.2023.100457
Multispectral optoacoustic tomography (MSOT) holds great promise as a non-invasive diagnostic tool for inflammatory bowel diseases. Yet, reliability and the impact of physiological processes during fasting and after food intake on optoacoustic signals have not been studied. In the present investigator initiated trial (NCT05160077) the intestines of ten healthy subjects were examined by MSOT at eight timepoints on two days, one fasting and one after food intake. While within-timepoint and within-day reproducibility were good for single wavelength 800 nm and total hemoglobin (ICC 0.722–0.956), between-day reproducibility was inferior (ICC −0.137 to 0.438). However, temporal variability was smaller than variation between individuals (coefficients of variation 8.9%−33.7% vs. 17.0%−48.5%). After food intake and consecutive increased intestinal circulation, indicated by reduced resistance index of simultaneous Doppler ultrasound, optoacoustic signals did not alter significantly. In summary, this study demonstrates high reliability and temporal stability of MSOT for imaging the human intestine during fasting and after food intake.
APA:
Paulus, L.-P., Wagner, A., Buehler, A., Raming, R., Jüngert, J., Simon, D.,... Regensburger, A. (2023). Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow. Photoacoustics, 30. https://doi.org/10.1016/j.pacs.2023.100457
MLA:
Paulus, Lars-Philip, et al. "Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow." Photoacoustics 30 (2023).
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