Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection
Graw F, Richter K, Oxenius A, Regoes RR (2011)
Publication Type: Journal article
Publication year: 2011
Journal
Book Volume: 278
Pages Range: 3395-3402
Journal Issue: 1723
Abstract
Immune responses mediated by cytotoxic T lymphocytes (CTLs) have often been found to be functionally impaired in persistent infections. It is assumed that this impairment contributes to persistence of the infection. In this study, we compare the killing efficacy of CD8+ T-cell responses in mice acutely and persistently infected with the lymphocytic choriomeningitis virus, using an in vivo CTL killing assay. To infer the killing efficacy of CTLs, we developed a new mathematical model describing the disappearance of peptide-pulsed cells from the blood of the mice over time. We estimate a lower half-life for peptidepulsed cells in acute infection than in persistent infection, which indicates a higher killing efficacy of the CD8+ T-cell response in acute infection. However, by controlling for the different levels of CTLs in acutely and persistently infected mice, we find that CTLs in persistent infection are only two times less efficacious than CTLs in acute infections. These results strongly suggest that the in vivo cytotoxicity of CD8+ T-cell responses in persistent infection is modulated via the number of CTLs rather than their individual functionality. © 2011 The Royal Society.
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Switzerland (CH)How to cite
APA:
Graw, F., Richter, K., Oxenius, A., & Regoes, R.R. (2011). Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection. Proceedings of the Royal Society of London, Series B: Biological Sciences, 278(1723), 3395-3402. https://doi.org/10.1098/rspb.2011.0453
MLA:
Graw, Frederik, et al. "Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection." Proceedings of the Royal Society of London, Series B: Biological Sciences 278.1723 (2011): 3395-3402.
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