The role of AMPA and NMDA receptors in mitragynine effects on hippocampal synaptic plasticity
Effendy MA, Yunusa S, Mat NH, Has ATC, Müller CP, Hassan Z (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 438
Article Number: 114169
DOI: 10.1016/j.bbr.2022.114169
Abstract
Mitragynine, an indole alkaloid from the plant Mitragyna speciosa (Kratom), has been reported to modify hippocampal synaptic transmission. However, the role of glutamatergic neurotransmission modulating synaptic plasticity in mitragynine-induced synaptic changes is still unknown. Here, we determined the role of AMPA- and NMDA glutamate receptors in mitragynine-induced synaptic plasticity in the hippocampus. Male Sprague Dawley rats received either vehicle or mitragynine (10 mg/kg), with or without the AMPA receptor antagonist, NBQX (3 mg/kg), or the NMDA receptor antagonist, MK-801 (0.2 mg/kg). Field excitatory postsynaptic potentials (fEPSP) during baseline, paired-pulse facilitation (PPF) and long-term potentiation (LTP) were recorded in-vivo in the hippocampal CA1 area of anaesthetised rats. Basal synaptic transmission and LTP were significantly impaired after mitragynine, NBQX, and MK-801 alone, without an effect on PPF. Combined effects suggest a weak functional AMPA- as well as NMDA receptor antagonist action of mitragynine.
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APA:
Effendy, M.A., Yunusa, S., Mat, N.H., Has, A.T.C., Müller, C.P., & Hassan, Z. (2023). The role of AMPA and NMDA receptors in mitragynine effects on hippocampal synaptic plasticity. Behavioural Brain Research, 438. https://doi.org/10.1016/j.bbr.2022.114169
MLA:
Effendy, Mohamad Azmeer, et al. "The role of AMPA and NMDA receptors in mitragynine effects on hippocampal synaptic plasticity." Behavioural Brain Research 438 (2023).
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