Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages

Royzman D, Peckert-Maier K, Stich L, König C, Wild A, Tauchi M, Ostalecki C, Kiesewetter F, Seyferth S, Lee G, Eming SA, Fuchs M, Kunz M, Stürmer EK, Peters EM, Berking C, Zinser E, Steinkasserer A (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 13

Article Number: 1012647

DOI: 10.3389/fimmu.2022.1012647

Abstract

To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated wound healing not only after systemic but also after topical application, which is of high therapeutic interest. Cytokine profile analyses revealed an initial upregulation of inflammatory mediators such as TNFα and IL-1β, followed by a switch towards pro-resolving factors, including YM-1 and IL-10, both expressed by tissue repair macrophages. These cells are known to mediate resolution of inflammation and stimulate wound healing processes by secretion of growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), which promote vascularization as well as fibroblast and keratinocyte differentiation. In conclusion, we have found strong wound healing capacities of sCD83 beyond the previously described role in transplantation and autoimmunity. This makes sCD83 a promising candidate for the treatment of chronic- and hard-to-heal wounds.

Authors with CRIS profile

Dmytro Royzman Department of Immune Modulation Christina König Department of Immune Modulation Andreas Wild Lehrstuhl für Biochemie und Molekulare Medizin Miyuki Tauchi-Brück Department of Medicine 2 – Cardiology and Angiology Franklin Kiesewetter Medizinische Fakultät Stefan Seyferth Lehrstuhl für Pharmazeutische Technologie und Biopharmazie Geoffrey Lee Lehrstuhl für Pharmazeutische Technologie und Biopharmazie Meik Kunz
Carola Berking Lehrstuhl für Haut- und Geschlechtskrankheiten Elisabeth Zinser Medizinische Fakultät Alexander Steinkasserer Professur für Experimentelle Dermatologie

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

A089: CD83 as a key regulator during immune homeostasis and neuroinflammation July 1, 2020 - June 30, 2023

Involved external institutions

Universitätsklinikum Köln DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Fraunhofer-Institut für Toxikologie und Experimentelle Medizin (ITEM) / Fraunhofer Institute for Toxicology and Experimental Medicine DE Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE)

How to cite

APA:

Royzman, D., Peckert-Maier, K., Stich, L., König, C., Wild, A., Tauchi, M.,... Steinkasserer, A. (2022). Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1012647

MLA:

Royzman, Dmytro, et al. "Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages." Frontiers in Immunology 13 (2022).

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