A Highly Water- and Air-Stable Iron-Containing MRI Contrast Agent Sensor for H2O2

Karbalaei S, Franke A, Jordan A, Rose C, Pokkuluri PR, Beyers RJ, Zahl A, Ivanović-Burmazović I, Goldsmith CR (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Chemistry - A European Journal Wiley

DOI: 10.1002/chem.202201179

Abstract

A highly water- and air-stable Fe(II) complex with the quinol-containing macrocyclic ligand H4qp4 reacts with H2O2 to yield Fe(III) complexes with less highly chelating forms of the ligand that have either one or two para-quinones. The reaction increases the T1-weighted relaxivity over four-fold, enabling the complex to detect H2O2 using clinical MRI technology. The iron-containing sensor differs from its recently characterized manganese analog, which also detects H2O2, in that it is the oxidation of the metal center, rather than the ligand, that primarily enhances the relaxivity.

Authors with CRIS profile

Achim Zahl Lehrstuhl für Chemistry of thin film materials

Involved external institutions

Auburn University US United States (USA) (US) Ludwig-Maximilians-Universität (LMU) DE Germany (DE)

How to cite

APA:

Karbalaei, S., Franke, A., Jordan, A., Rose, C., Pokkuluri, P.R., Beyers, R.J.,... Goldsmith, C.R. (2022). A Highly Water- and Air-Stable Iron-Containing MRI Contrast Agent Sensor for H2O2. Chemistry - A European Journal. https://doi.org/10.1002/chem.202201179

MLA:

Karbalaei, Sana, et al. "A Highly Water- and Air-Stable Iron-Containing MRI Contrast Agent Sensor for H2O2." Chemistry - A European Journal (2022).

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