Quantification of drug-loaded magnetic nanoparticles in rabbit liver and tumor after in vivo administration
Tietze R, Jurgons R, Lyer S, Schreiber E, Wiekhorst F, Eberbeck D, Richter H, Steinhoff U, Trahms L, Alexiou C (2009)
Publication Type: Journal article
Publication year: 2009
Journal
Book Volume: 321
Pages Range: 1465-1468
Journal Issue: 10
DOI: 10.1016/j.jmmm.2009.02.068
Abstract
Magnetic nanoparticles have been investigated for biomedical applications for more than 30 years. The development of biocompatible nanosized drug delivery systems for specific targeting of therapeutics is imminent in medical research, especially for treating cancer and vascular diseases. We used drug-labeled magnetic iron oxide nanoparticles, which were attracted to an experimental tumor in rabbits with an external magnetic field (magnetic drug targeting, MDT). Aim of this study was to detect and quantify the biodistribution of the magnetic nanoparticles by magnetorelaxometry. The study shows higher amount of nanoparticles in the tumor after intraarterial application and MDT compared to intravenous administration.
Authors with CRIS profile
Rainer Tietze
Department of Otorhinolaryngology – Head and Neck Surgery
Stefan Lyer
Department of Otorhinolaryngology – Head and Neck Surgery
Christoph Alexiou
Professur für Nanomedizin
Involved external institutions
Germany (DE)How to cite
APA:
Tietze, R., Jurgons, R., Lyer, S., Schreiber, E., Wiekhorst, F., Eberbeck, D.,... Alexiou, C. (2009). Quantification of drug-loaded magnetic nanoparticles in rabbit liver and tumor after in vivo administration. Journal of Magnetism and Magnetic Materials, 321(10), 1465-1468. https://doi.org/10.1016/j.jmmm.2009.02.068
MLA:
Tietze, Rainer, et al. "Quantification of drug-loaded magnetic nanoparticles in rabbit liver and tumor after in vivo administration." Journal of Magnetism and Magnetic Materials 321.10 (2009): 1465-1468.
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