Home Publications Research Grants Inventions & Patents Awards Additional Research Activities Faculties & Institutions Research Areas

Cancer therapy with drug loaded magnetic nanoparticlesmagnetic drug targeting

Alexiou C, Tietze R, Schreiber E, Jurgons R, Richter H, Trahms L, Rahn H, Odenbach S, Lyer S (2011)

---

Publication Type: Journal article

Publication year: 2011

Journal

Book Volume: 323

Pages Range: 1404-1407

Journal Issue: 10

DOI: 10.1016/j.jmmm.2010.11.059

Abstract

The aim of magnetic drug targeting (MDT) in cancer therapy is to concentrate chemotherapeutics to a tumor region while simultaneously the overall dose is reduced. This can be achieved with coated superparamagnetic nanoparticles bound to a chemotherapeutic agent. These particles are applied intra arterially close to the tumor region and focused to the tumor by a strong external magnetic field. The interaction of the particles with the field gradient leads to an accumulation in the region of interest (i.e. tumor). The particle enrichment and thereby the drug-load in the tumor during MDT has been proven by several analytical and imaging methods. Moreover, in pilot studies we investigated in an experimental in vivo tumor model the effectiveness of this approach. Complete tumor regressions without any negative side effects could be observed. © 2010 Elsevier B.V. All rights reserved.

Authors with CRIS profile

Involved external institutions

How to cite

APA:

Alexiou, C., Tietze, R., Schreiber, E., Jurgons, R., Richter, H., Trahms, L.,... Lyer, S. (2011). Cancer therapy with drug loaded magnetic nanoparticlesmagnetic drug targeting. Journal of Magnetism and Magnetic Materials, 323(10), 1404-1407. https://dx.doi.org/10.1016/j.jmmm.2010.11.059

MLA:

Alexiou, Christoph, et al. "Cancer therapy with drug loaded magnetic nanoparticlesmagnetic drug targeting." Journal of Magnetism and Magnetic Materials 323.10 (2011): 1404-1407.

BibTeX: Download