Bivalent Peptide- A nd Chelator-Containing Bioconjugates as Toolbox Components for Personalized Nanomedicine

Daeg J, Xu X, Zhao L, Boye S, Janke A, Temme A, Zhao J, Lederer A, Voit B, Shi X, Appelhans D (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Biomacromolecules American Chemical Society

Book Volume: 21

Pages Range: 199-213

Journal Issue: 1

DOI: 10.1021/acs.biomac.9b01127

Abstract

While personalized therapy bears an enormous potential in cancer therapy, the development of flexible, tailorable delivery systems remains challenging. Here, we present a "tool-kit" of various avidin-based bioconjugates (BCs) for the preparation of personalized delivery systems. Corresponding BCs were synthesized using the self-assembly of avidin with various biotinylated ligands, such as one cationic glycodendrimer for dendriplex adsorption and two functional ligands for imaging (glycodendrimers with DOTA or NOTA units) or targeting (biotinylated PEG decorated with ligands). Substituting antibodies for targeting small molecules were coupled to biotin-PEG compounds for addressing the folate receptor (FR), epidermal growth factor receptor (EGFR), and prostate-specific membrane antigen (PSMA). After successful characterization and proof of good storage and redispersion properties of BCs, cytotoxicity assays and first in vivo imaging studies with 99mTc-complexing bioconjugates provide evidence that these BCs and their avidin analogues can be used as tool-kit components in theranostic systems for personalized medicine.

Involved external institutions

Leibniz-Institut für Polymerforschung Dresden e. V. DE Germany (DE) Shanghai Jiao Tong University / 上海交通大学 CN China (CN) Universitätsklinikum Carl Gustav Carus Dresden DE Germany (DE)

How to cite

APA:

Daeg, J., Xu, X., Zhao, L., Boye, S., Janke, A., Temme, A.,... Appelhans, D. (2020). Bivalent Peptide- A nd Chelator-Containing Bioconjugates as Toolbox Components for Personalized Nanomedicine. Biomacromolecules, 21(1), 199-213. https://doi.org/10.1021/acs.biomac.9b01127

MLA:

Daeg, Jennifer, et al. "Bivalent Peptide- A nd Chelator-Containing Bioconjugates as Toolbox Components for Personalized Nanomedicine." Biomacromolecules 21.1 (2020): 199-213.

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