Comparison of Cellular Target Engagement Methods for the Tubulin Deacetylases Sirt2 and HDAC6: NanoBRET, CETSA, Tubulin Acetylation, and PROTACs

Vogelmann A, Jung M, Hansen FK, Schiedel M (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

ACS Pharmacology & Translational Science American Chemical Society

Book Volume: 5

Pages Range: 138-140

Journal Issue: 2

DOI: 10.1021/acsptsci.2c00004

Abstract

The tubulin deacetylases Sirt2 and HDAC6 have been associated with the development of various diseases. Herein, we discuss recent approaches that enable cellular target engagement studies for these deacetylases and thus play a critical role in the evaluation of small molecule inhibitors of Sirt2 or HDAC6 as potential therapeutic agents.

Authors with CRIS profile

Matthias Schiedel Lehrstuhl für Pharmazeutische Chemie

Involved external institutions

Albert-Ludwigs-Universität Freiburg DE Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE)

How to cite

APA:

Vogelmann, A., Jung, M., Hansen, F.K., & Schiedel, M. (2022). Comparison of Cellular Target Engagement Methods for the Tubulin Deacetylases Sirt2 and HDAC6: NanoBRET, CETSA, Tubulin Acetylation, and PROTACs. ACS Pharmacology & Translational Science, 5(2), 138-140. https://doi.org/10.1021/acsptsci.2c00004

MLA:

Vogelmann, Anja, et al. "Comparison of Cellular Target Engagement Methods for the Tubulin Deacetylases Sirt2 and HDAC6: NanoBRET, CETSA, Tubulin Acetylation, and PROTACs." ACS Pharmacology & Translational Science 5.2 (2022): 138-140.

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