Aminoferrocene-Based Anticancer Prodrugs Labelled with Cyanine Dyes for in vivo Imaging

Özkan H, Toms J, Maschauer S, Prante O, Mokhir A (2021)

Publication Type: Journal article

Publication year: 2021

Journal

European Journal of Inorganic Chemistry Wiley-VCH Verlag

DOI: 10.1002/ejic.202100829

Abstract

N-alkylaminoferrocene-based (NAAF) prodrugs are activated in the presence of reactive oxygen species (ROS), based on which these prodrugs target cancer cells (high ROS) and do not affect normal cells (low ROS). To gain some insights into their mode of action in vivo, we have investigated the biodistribution of ¹⁸F-labelled NAAF prodrugs in tumor-bearing mice by positron emission tomography (PET). Due to the short half-life of ¹⁸F, the experimental time frame was restricted to 60 min. To extend the observation window, a more stable marker is required. In this paper, we report on conjugates of NAAF prodrugs with two cyanine dyes Cy5 and Cy7 including details of their synthesis, characterization and basic properties in cell free settings and their cellular uptake in representative human cancer cells. Finally, the Cy5 conjugate was subjected to in vivo fluorescence imaging studies to determine the prodrug biodistribution over 24 h.

Authors with CRIS profile

Hülya Özkan Professur für Organische Chemie Johannes Toms Department of Nuclear Medicine Simone Maschauer Professur für Molekulare Bildgebung und Radiochemie Olaf Prante Professur für Molekulare Bildgebung und Radiochemie Andriy Mokhir Professur für Organische Chemie

How to cite

APA:

Özkan, H., Toms, J., Maschauer, S., Prante, O., & Mokhir, A. (2021). Aminoferrocene-Based Anticancer Prodrugs Labelled with Cyanine Dyes for in vivo Imaging. European Journal of Inorganic Chemistry. https://dx.doi.org/10.1002/ejic.202100829

MLA:

Özkan, Hülya, et al. "Aminoferrocene-Based Anticancer Prodrugs Labelled with Cyanine Dyes for in vivo Imaging." European Journal of Inorganic Chemistry (2021).

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