Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

Li N, Mirzakhani H, Kiefer A, Kölle J, Vuorinen T, Rauh M, Yang Z, Krammer S, Xepapadaki P, Lewandowska-Polak A, Lukkarinen H, Zhang N, Stanic B, Zimmermann T, Kowalski ML, Jartti T, Bachert C, Akdis M, Papadopoulos NG, Raby BA, Weiss ST, Neurath-Finotto S (2021)

Publication Type: Journal article

Publication year: 2021

Journal

iScience Elsevier

Book Volume: 24

Journal Issue: 10

DOI: 10.1016/j.isci.2021.103163

Abstract

RANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.

Authors with CRIS profile

Nina Li Professur für Molekulare Pneumologie Julia Kölle Department of Molecular Pneumology Manfred Rauh Department of Paediatrics and Adolescent Medicine Zuqin Yang Department of Molecular Pneumology Susanne Krammer Department of Molecular Pneumology Theodor Zimmermann Medizinische Fakultät Susetta Neurath-Finotto Professur für Molekulare Pneumologie

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

A082: Understanding the role of RANTES in the resolution of allergic asthma Feb. 1, 2020 - Jan. 31, 2023

Involved external institutions

Medical University of Łódź / Uniwersytet Medyczny w Łodzi PL Poland (PL) Universiteit Gent (UGent) / Ghent University BE Belgium (BE) Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS) FI Finland (FI) University of Turku / Turun yliopisto FI Finland (FI) University of Zurich / Universität Zürich (UZH) CH Switzerland (CH) Harvard University US United States (USA) (US) National and Kapodistrian University of Athens GR Greece (GR)

How to cite

APA:

Li, N., Mirzakhani, H., Kiefer, A., Kölle, J., Vuorinen, T., Rauh, M.,... Neurath-Finotto, S. (2021). Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma. iScience, 24(10). https://doi.org/10.1016/j.isci.2021.103163

MLA:

Li, Nina, et al. "Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma." iScience 24.10 (2021).

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