PCL micro-dumbbells - A new class of polymeric particles reveals morphological biofunctionality

Sonnleitner D, Schaefer N, Wieland A, Fischer L, Pasberg P, Thievessen I, Lang G (2021)

Publication Type: Journal article

Publication year: 2021


Book Volume: 24

DOI: 10.1016/j.apmt.2021.101097


Biopolymeric particles can be fibrous or spherical, highly determining their areas of medical applications such as biomimetic fibers for tissue engineering or injectable capsules. In this work, we present a completely novel morphology, combining structural features of fibers and spheres in dumbbell-shaped Poly-epsilon-Caprolactone (PCL) micro-particles. Strikingly, such complex structures could be achieved by simply balancing out the parameters of a standard electrospinning setup together with fine-tuned spinning dope compositions. In-situ entropy-elastic snapping of deposited fibers could be triggered by combining PCL with different molecular weights, allowing for control over the aspect ratio of generated dumbbells in an accurate manner. With a single electrospinning nozzle, high production rates in the range of 80.000 dumbbells per second were achieved. To assess morphologically induced biofunctionality, dumbbell suspending and surface modification with collagen was performed and in vitro-testing with U87 reporter cells demonstrated significantly enhanced integrin-based cell adhesion on PCL-dumbbells as compared to continuous PCL-fibers. The results clearly unravel the remarkable potential of such structures in the field of tissue engineering. Revealing this new class of polymeric particles will also open the door to various new approaches including injectables, biofabrication and cosmetics, moreover, defining a novel type of filler material. (C) 2021 The Authors. Published by Elsevier Ltd.

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Sonnleitner, D., Schaefer, N., Wieland, A., Fischer, L., Pasberg, P., Thievessen, I., & Lang, G. (2021). PCL micro-dumbbells - A new class of polymeric particles reveals morphological biofunctionality. Applied Materials Today, 24. https://dx.doi.org/10.1016/j.apmt.2021.101097


Sonnleitner, David, et al. "PCL micro-dumbbells - A new class of polymeric particles reveals morphological biofunctionality." Applied Materials Today 24 (2021).

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