The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus

Gupta B, Errington AC, Jimenez-Pascual A, Eftychidis V, Brabletz S, Stemmler M, Brabletz T, Petrik D, Siebzehnrubl FA (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Cell Reports Elsevier (Cell Press)

Book Volume: 36

Journal Issue: 8

DOI: 10.1016/j.celrep.2021.109588

Abstract

Radial glia-like (RGL) stem cells persist in the adult mammalian hippocampus, where they generate new neurons and astrocytes throughout life. The process of adult neurogenesis is well documented, but cell-autonomous factors regulating neuronal and astroglial differentiation are incompletely understood. Here, we evaluate the functions of the transcription factor zinc-finger E-box binding homeobox 1 (ZEB1) in adult hippocampal RGL cells using a conditional-inducible mouse model. We find that ZEB1 is necessary for self-renewal of active RGL cells. Genetic deletion of Zeb1 causes a shift toward symmetric cell division that consumes the RGL cell and generates pro-neuronal progenies, resulting in an increase of newborn neurons and a decrease of newly generated astrocytes. We identify ZEB1 as positive regulator of the ets-domain transcription factor ETV5 that is critical for asymmetric division.

Authors with CRIS profile

Simone Brabletz Lehrstuhl für Experimentelle Medizin II (Molekulare Tumorforschung) Marc Stemmler Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung Thomas Brabletz Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung

Involved external institutions

Cardiff University GB United Kingdom (GB)

How to cite

APA:

Gupta, B., Errington, A.C., Jimenez-Pascual, A., Eftychidis, V., Brabletz, S., Stemmler, M.,... Siebzehnrubl, F.A. (2021). The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus. Cell Reports, 36(8). https://doi.org/10.1016/j.celrep.2021.109588

MLA:

Gupta, Bhavana, et al. "The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus." Cell Reports 36.8 (2021).

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