Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility
Montefusco-Pereira C, Formicola B, Goes A, Re F, Marrano CA, Mantegazza F, Carvalho-Wodarz C, Fuhrmann G, Caneva E, Nicotra F, Lehr CM, Russo L (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 149
Pages Range: 12-20
DOI: 10.1016/j.ejpb.2020.01.013
Abstract
By functionalizing the surface of PEG-liposomes with linkers bearing quaternary ammonium compounds (QACs), we generated novel bacteria disruptors with anti-adhesive properties and reduced cytotoxicity compared to free QACs. Furthermore, QAC-functionalized liposomes are a promising platform for future drug encapsulation. The QAC (11-mercaptoundecyl)-N,N,N-trimethylammonium bromide (MTAB) was attached to maleimide-functionalized liposomes (DSPE-PEG) via thiol linker. The MTAB-functionalized liposomes were physicochemically characterized and their biological activity, in terms of anti-adherence activity and biofilm prevention in Escherichia coli were assessed. The results showed that MTAB-functionalized liposomes inhibit bacterial adherence and biofilm formation while reducing MTAB toxicity.
Authors with CRIS profile
Involved external institutions
University of Milano-Bicocca / Università degli Studi di Milano-Bicocca, UNIMIB
Italy (IT)
Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)
Germany (DE)
Universität des Saarlandes (UdS)
Germany (DE)
Università degli studi di Milano
Italy (IT)
Italy (IT)
Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)
Germany (DE)
Universität des Saarlandes (UdS)
Germany (DE)
Università degli studi di Milano
Italy (IT)
How to cite
APA:
Montefusco-Pereira, C., Formicola, B., Goes, A., Re, F., Marrano, C.A., Mantegazza, F.,... Russo, L. (2020). Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility. European Journal of Pharmaceutics and Biopharmaceutics, 149, 12-20. https://doi.org/10.1016/j.ejpb.2020.01.013
MLA:
Montefusco-Pereira, Carlos, et al. "Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility." European Journal of Pharmaceutics and Biopharmaceutics 149 (2020): 12-20.
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