Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics

Wank I, Pliota P, Badurek S, Kraitsy K, Kaczanowska J, Griessner J, Kreitz S, Heß A, Haubensak W (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Communications Biology Nature Research

Book Volume: 4

Article Number: 732

Journal Issue: 1

DOI: 10.1038/s42003-021-02262-3

Abstract

The central amygdala (CE) emerges as a critical node for affective processing. However, how CE local circuitry interacts with brain wide affective states is yet uncharted. Using basic nociception as proxy, we find that gene expression suggests diverging roles of the two major CE neuronal populations, protein kinase C δ-expressing (PKCδ+) and somatostatin-expressing (SST+) cells. Optogenetic (o)fMRI demonstrates that PKCδ+/SST+ circuits engage specific separable functional subnetworks to modulate global brain dynamics by a differential bottom-up vs. top-down hierarchical mesoscale mechanism. This diverging modulation impacts on nocifensive behavior and may underly CE control of affective processing.

Authors with CRIS profile

Isabel Wank Institut für Experimentelle und Klinische Pharmakologie und Toxikologie Silke Kreitz Lehrstuhl für Pharmakologie und Toxikologie Andreas Heß Medizinische Fakultät

Involved external institutions

Forschungsinstitut für Molekulare Pathologie / Research Institute of Molecular Pathology (IMP) AT Austria (AT) Vienna Biocenter VBC AT Austria (AT)

How to cite

APA:

Wank, I., Pliota, P., Badurek, S., Kraitsy, K., Kaczanowska, J., Griessner, J.,... Haubensak, W. (2021). Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics. Communications Biology, 4(1). https://dx.doi.org/10.1038/s42003-021-02262-3

MLA:

Wank, Isabel, et al. "Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics." Communications Biology 4.1 (2021).

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