Hatscher L, Lehmann C, Purbojo A, Onderka C, Liang C, Hartmann A, Cesnjevar R, Bruns H, Gross O, Nimmerjahn F, Burmazovic II, Kunz M, Heger L, Dudziak D (2021)
Publication Language: English
Publication Type: Journal article, Original article
Publication year: 2021
Book Volume: 14
Pages Range: 1-17
Article Number: abe1757
Journal Issue: 680
URI: https://stke.sciencemag.org/content/14/680/eabe1757
DOI: 10.1126/scisignal.abe1757
The detection of microorganisms and danger signals by pattern recognition receptors on dendritic cells (DCs) and the consequent formation of inflammasomes are pivotal for initiating protective immune responses. Although the activation of inflammasomes leading to secretion of the cytokine IL-1 is typically accompanied by pyroptosis (an inflammatory form of lytic programmed cell death), some cells can survive and exist in a state of hyperactivation. Here, we found that the conventional type 2 DC (cDC2) subset is the major human DC subset that is transcriptionally and functionally poised for inflammasome formation and response without pyroptosis. When cDC2 were stimulated with ligands that relatively weakly activated the inflammasome, the cells did not enter pyroptosis but instead secreted IL-12 family cytokines and IL-1. These cytokines induced prominent T helper type 1 (TH1) and TH17 responses that were superior to those seen in response to Toll-like receptor (TLR) stimulation alone or to stronger, classical inflammasome ligands. These findings not only define the human cDC2 subpopulation as a prime target for the treatment of inflammasome-dependent inflammatory diseases but may also inform new approaches for adjuvant and vaccine development.
APA:
Hatscher, L., Lehmann, C., Purbojo, A., Onderka, C., Liang, C., Hartmann, A.,... Dudziak, D. (2021). Select hyperactivating NLRP3 ligands enhance the TH1-and TH17-inducing potential of human type 2 conventional dendritic cells. Science Signaling, 14(680), 1-17. https://doi.org/10.1126/scisignal.abe1757
MLA:
Hatscher, Lukas, et al. "Select hyperactivating NLRP3 ligands enhance the TH1-and TH17-inducing potential of human type 2 conventional dendritic cells." Science Signaling 14.680 (2021): 1-17.
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