A080: Control of immune responses by inflammasomes in primary dendritic cells
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2020
End date : 30.06.2022
Extension date: 31.12.2022
Project details
Scientific Abstract
Inflammasomes play a pivotal role in the immune response against pathogens, but also in the pathogenesis of inflammatory disorders. Our data indicate that inflammasome activation in DCs is leading to full DC stimulation without induction of pyroptosis. We hypothesize that uncontrolled inflammasome stimulation in DCs might be key component in inflammatory disorders. In this study, we want to elucidate the mechanisms in this specific inflammasome activation in primary DC.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Professur für die Biologie Dendritischer Zellen
Medizinische Fakultät
