Cationic Aluminium Complexes as Catalysts for Imine Hydrogenation

Friedrich A, Eyselein J, Elsen H, Langer J, Pahl J, Wiesinger M, Harder S (2021)

Publication Type: Journal article

Publication year: 2021

Journal

DOI: 10.1002/chem.202100641

Abstract

Strongly Lewis acidic cationic aluminium complexes, stabilized by β–diketiminate (BDI) ligands and free of Lewis bases, have been prepared as their B(C6F5)4⁻ salts and were investigated for catalytic activity in imine hydrogenation. The backbone (R1) and N (R2) substituents on the ^R1,R2BDI ligand (^R1,R2BDI=HC[C(R1)N(R2)]2) influence sterics and Lewis acidity. Ligand bulk increases along the row ^Me,DIPPBDI<^Me,DIPePBDI≈^tBu,DIPPBDI<^tBu,DIPePBDI; DIPP=2,6-C(H)Me2-phenyl, DIPeP=2,6-C(H)Et2-phenyl. The Gutmann-Beckett test showed acceptor numbers of: (^tBu,DIPPBDI)AlMe⁺ 85.6, (^tBu,DIPePBDI)AlMe⁺ 85.9, (^Me,DIPPBDI)AlMe⁺ 89.7, (^Me,DIPePBDI)AlMe⁺ 90.8, (^Me,DIPPBDI)AlH⁺ 95.3. Steric and electronic factors need to be balanced for catalytic activity in imine hydrogenation. Open, highly Lewis acidic, cations strongly coordinate imine rendering it inactive as a Frustrated Lewis Pair (FLP). The bulkiest cations do not coordinate imine but its combination is also not an active catalyst. The cation (^tBu,DIPPBDI)AlMe⁺ shows the best catalytic activity for various imines and is also an active catalyst for the Tishchenko reaction of benzaldehyde to benzylbenzoate. DFT calculations on the mechanism of imine hydrogenation catalysed by cationic Al complexes reveal two interconnected catalytic cycles operating in concert. Hydrogen is activated either by FLP reactivity of an Al⋅⋅⋅imine couple or, after formation of significant quantities of amine, by reaction with an Al⋅⋅⋅amine couple. The latter autocatalytic Al⋅⋅⋅amine cycle is energetically favoured.

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How to cite

APA:

Friedrich, A., Eyselein, J., Elsen, H., Langer, J., Pahl, J., Wiesinger, M., & Harder, S. (2021). Cationic Aluminium Complexes as Catalysts for Imine Hydrogenation. Chemistry - A European Journal. https://doi.org/10.1002/chem.202100641

MLA:

Friedrich, Alexander, et al. "Cationic Aluminium Complexes as Catalysts for Imine Hydrogenation." Chemistry - A European Journal (2021).

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