Heimesaat MM, Backert S, Alter T, Bereswill S (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Book Volume: 431
Pages Range: 1-23
Zoonotic Campylobacter species-mainly C. jejuni and C. coli-are major causes of food-borne bacterial infectious gastroenteritis worldwide. Symptoms of intestinal campylobacteriosis include abdominal pain, diarrhea and fever. The clinical course of enteritis is generally self-limiting, but some infected individuals develop severe post-infectious sequelae including autoimmune disorders affecting the nervous system, the joints and the intestinal tract. Moreover, in immunocompromised individuals, systemic spread of the pathogens may trigger diseases of the circulatory system and septicemia. The socioeconomic costs associated with Campylobacter infections have been calculated to several billion dollars annually. Poultry meat products represent major sources of human infections. Thus, a "One World-One Health" approach with collective efforts of public health authorities, veterinarians, clinicians, researchers and politicians is required to reduce the burden of campylobacteriosis. Innovative intervention regimes for the prevention of Campylobacter contaminations along the food chain include improvements of information distribution to strengthen hygiene measures for agricultural remediation. Given that elimination of Campylobacter from the food production chains is not feasible, novel intervention strategies fortify both the reduction of pathogen contamination in food production and the treatment of the associated diseases in humans. This review summarizes some current trends in the combat of Campylobacter infections including the combination of public health and veterinary preventive approaches with consumer education. The "One World-One Health" perspective is completed by clinical aspects and molecular concepts of human campylobacteriosis offering innovative treatment options supported by novel murine infection models that are based on the essential role of innate immune activation by bacterial endotoxins.
Heimesaat, M.M., Backert, S., Alter, T., & Bereswill, S. (2021). Human Campylobacteriosis-A Serious Infectious Threat in a One Health Perspective. Current Topics in Microbiology and Immunology, 431, 1-23. https://dx.doi.org/10.1007/978-3-030-65481-8_1
Heimesaat, Markus M., et al. "Human Campylobacteriosis-A Serious Infectious Threat in a One Health Perspective." Current Topics in Microbiology and Immunology 431 (2021): 1-23.