Exploiting the gastric epithelial barrier: Helicobacter pylori’s attack on tight and adherens junctions
Backert S, Schmidt TP, Harrer A, Wessler S (2017)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2017
Journal
Publisher: Springer Verlag
Edited Volumes: Molecular Pathogenesis and Signal Transduction by Helicobacter pylori
Series: Current Topics in Microbiology and Immunology
City/Town: Cham
Book Volume: 400
Pages Range: 195-226
DOI: 10.1007/978-3-319-50520-6_9
Abstract
Highly organized intercellular tight and adherens junctions are crucial structural components for establishing and maintenance of epithelial barrier functions, which control the microbiota and protect against intruding pathogens in humans. Alterations in these complexes represent key events in the development and progression of multiple infectious diseases as well as various cancers. The gastric pathogen Helicobacter pylori exerts an amazing set of strategies to manipulate these epithelial cell-to-cell junctions, which are implicated in changing cell polarity, migration and invasive growth as well as pro-inflammatory and proliferative responses. This chapter focuses on the H. pylori pathogenicity factors VacA, CagA, HtrA and urease, and how they can induce host cell signaling involved in altering cell-to-cell permeability. We propose a stepwise model for how H. pylori targets components of tight and adherens junctions in order to disrupt the gastric epithelial cell layer, giving fresh insights into the pathogenesis of this important bacterium.
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Austria (AT)How to cite
APA:
Backert, S., Schmidt, T.P., Harrer, A., & Wessler, S. (2017). Exploiting the gastric epithelial barrier: Helicobacter pylori’s attack on tight and adherens junctions. In Nicole Tegtmeyer, Steffen Backert (Eds.), Molecular Pathogenesis and Signal Transduction by Helicobacter pylori. (pp. 195-226). Cham: Springer Verlag.
MLA:
Backert, Steffen, et al. "Exploiting the gastric epithelial barrier: Helicobacter pylori’s attack on tight and adherens junctions." Molecular Pathogenesis and Signal Transduction by Helicobacter pylori. Ed. Nicole Tegtmeyer, Steffen Backert, Cham: Springer Verlag, 2017. 195-226.
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