Cardiac Surgery is Associated with Biomarker Evidence of Neuronal Damage

Alifier M, Olsson B, Andreasson U, Cullen NC, Czyżewska J, Jakubów P, Sieśkiewicz A, Stasiak-Barmuta A, Hirnle T, Kornhuber J, Zetterberg H, Lewczuk P, Blennow K (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Journal of Alzheimer's Disease IOS Press

Book Volume: 74

Pages Range: 1211-1220

Journal Issue: 4

DOI: 10.3233/JAD-191165

Abstract

Background: Anesthesia and surgery is commonly associated with central nervous system sequelae and cognitive symptoms, which may be caused by neuronal injury. Neuronal injury can be monitored by plasma concentrations of the neuronal biomarkers tau and neurofilament light protein (NFL). Currently, there are no studies examining whether neuronal injury varies between surgical procedures. Objective: Our aim was to investigate if neuronal damage is more frequent after cardiac than after otolaryngeal surgery, as estimated by tau and NFL concentrations in plasma. Methods: Blood samples were drawn before, during, and after surgery and concentrations of tau, NFL, Aβ40, and Aβ42 were measured in 25 patients undergoing cardiac surgery (9 off-pump and 16 on-pump) and 26 patients undergoing otolaryngeal surgery. Results: Tau increased during surgery (1752%, p=0.0001) and NFL rose seven days post-surgery (1090%, p<0.0001) in patients undergoing cardiac surgery; even more in patients on-pump than off-pump. No changes were observed in patients undergoing otolaryngeal surgery and only minor fluctuations were observed for Aβ40 and Aβ42. Conclusion: Cardiac surgery is associated with neuronal injury, which is aggravated by extracorporeal circulation. Analyses of NFL and tau in blood may guide development of surgical procedures to minimize neuronal damage, and may also be used in longitudinal clinical studies to assess the relationship of surgery with future neurocognitive impairment or dementia.

Authors with CRIS profile

Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie Piotr Lewczuk Department of Psychiatry and Psychotherapy

Involved external institutions

Medical University of Bialystok PL Poland (PL) Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset SE Sweden (SE)

How to cite

APA:

Alifier, M., Olsson, B., Andreasson, U., Cullen, N.C., Czyżewska, J., Jakubów, P.,... Blennow, K. (2020). Cardiac Surgery is Associated with Biomarker Evidence of Neuronal Damage. Journal of Alzheimer's Disease, 74(4), 1211-1220. https://doi.org/10.3233/JAD-191165

MLA:

Alifier, Marek, et al. "Cardiac Surgery is Associated with Biomarker Evidence of Neuronal Damage." Journal of Alzheimer's Disease 74.4 (2020): 1211-1220.

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