Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, Draganov D, Edelson RL, Formenti SC, Fucikova J, Gabriele L, Gaipl U, Gameiro SR, Garg AD, Golden E, Han J, Harrington KJ, Hemminki A, Hodge JW, Hossain DMS, Illidge T, Karin M, Kaufman HL, Kepp O, Kroemer G, Lasarte JJ, Loi S, Lotze MT, Manic G, Merghoub T, Melcher AA, Mossman KL, Prosper F, Rekdal Ø, Rescigno M, Riganti C, Sistigu A, Smyth MJ, Spisek R, Stagg J, Strauss BE, Tang D, Tatsuno K, Van Gool SW, Vandenabeele P, Yamazaki T, Zamarin D, Zitvogel L, Cesano A, Marincola FM (2020)

Publication Type: Journal article, Review article

Publication year: 2020

Journal

Book Volume: 8

Article Number: e000337

Journal Issue: 1

DOI: 10.1136/jitc-2019-000337

Abstract

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

Authors with CRIS profile

Involved external institutions

NanoString Technologies, Inc. United States (USA) (US) Weill Cornell Medicine United States (USA) (US) Istituto Italiano per la Medicina Genomica / Italian Institute for Genomic Medicine (IIGM) Italy (IT) Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB) Belgium (BE) Yale School of Medicine United States (USA) (US) Motol University Hospital / Fakultní nemocnice v Motole Czech Republic (CZ) Stabilité génétique et oncogenèse France (FR) Lytix Biopharma AS Norway (NO) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU) Istituto di ricovero e cura a carattere scientifico (IRCCS) Italy (IT) Immunologisches und onkologisches Zentrum Köln GmbH & Co. KG Germany (DE) Humanitas Research Hospital / IRCCS Istituto Clinico Humanitas Italy (IT) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) iRepertoire, Inc. United States (USA) (US) University of Turin / Università degli Studi di Torino (UNITO) Italy (IT) Italian National Health Institute / Istituto Superiore di Sanità (ISS) Italy (IT) Calidi Biotherapeutics. United States (USA) (US) Memorial Sloan Kettering Cancer Center United States (USA) (US) University of Manchester United Kingdom (GB) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) Universidad de Navarra Spain (ES) McMaster University Canada (CA) University of Pittsburgh United States (USA) (US) Centre hospitalier de l'Université de Montréal (CHUM) Canada (CA) Peter MacCallum Cancer Centre Australia (AU) Refuge Biotechnologies Inc United States (USA) (US) University of California, San Diego United States (USA) (US) Massachusetts General Hospital United States (USA) (US) Merck & Co., Inc. / Merck Sharp & Dohme Corp (MSD) United States (USA) (US) University of Texas Southwestern Medical Center (UT Southwestern) United States (USA) (US) National Cancer Institute (NCI) United States (USA) (US) Essa Pharma, Inc. United States (USA) (US) Helsingin yliopisto / University of Helsinki Finland (FI) École Polytechnique - Université Paris-Saclay France (FR) The Institute of Cancer Research (ICR) United Kingdom (GB) Université de Lausanne (UNIL) Switzerland (CH)

How to cite

APA:

Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Martinez, A.B.,... Marincola, F.M. (2020). Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. Journal for ImmunoTherapy of Cancer, 8(1). https://doi.org/10.1136/jitc-2019-000337

MLA:

Galluzzi, Lorenzo, et al. "Consensus guidelines for the definition, detection and interpretation of immunogenic cell death." Journal for ImmunoTherapy of Cancer 8.1 (2020).

BibTeX: Download