Setting behavior and bioactivity assessment of calcium carbonate cements

Rodríguez-Sánchez J, Myszka B, Boccaccini AR, Dysthe DK (2019)

Publication Type: Journal article

Publication year: 2019


Book Volume: 102

Pages Range: 6980-6990

Journal Issue: 11

DOI: 10.1111/jace.16593


Calcium carbonate cements have emerged in the last few years as an attractive candidate for biomedical applications. They can be easily prepared by mixing water with two metastable calcium carbonate phases––amorphous calcium carbonate (ACC) and vaterite––which (re)crystallize into calcite during setting reaction. The transformation kinetics (and therefore the final surface cement composition) strongly depends on the initial mixture design and is controlled by the dissolution of ACC, whereas calcite nucleation typically controls their recrystallization in fluid batch experiments. Novel compositions are presented in this paper by incorporating organic molecules as a proxy to test their capability to carry on other biomolecules like proteins or antibiotics. The hardened samples are microporous and show excellent bioactivity rates, although their mechanical properties still remain poor. However, this would not be a handicap for in-vivo applications such as bone filling, especially in low mechanical stress locations.

Authors with CRIS profile

Involved external institutions

How to cite


Rodríguez-Sánchez, J., Myszka, B., Boccaccini, A.R., & Dysthe, D.K. (2019). Setting behavior and bioactivity assessment of calcium carbonate cements. Journal of the American Ceramic Society, 102(11), 6980-6990.


Rodríguez-Sánchez, Jesús, et al. "Setting behavior and bioactivity assessment of calcium carbonate cements." Journal of the American Ceramic Society 102.11 (2019): 6980-6990.

BibTeX: Download