Magnetic microgels for drug targeting applications: Physical--chemical properties and cytotoxicity evaluation

Turcu R, Craciunescu I, Garamus VM, Janko C, Lyer S, Tietze R, Alexiou C, Vekas L (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Journal of Magnetism and Magnetic Materials Elsevier

Book Volume: 380

Pages Range: 307-314

DOI: 10.1016/j.jmmm.2014.08.041

Abstract

Magnetoresponsive microgels with high saturation magnetization values have been obtained by a strategy based on the miniemulsion method using high colloidal stability organic carrier ferrofluid as primary material. Hydrophobic nanoparticles Fe3O4/oleic acid are densely packed into well-defined spherical nanoparticle clusters coated with polymers with sizes in the range 40--350 nm. Physical-- chemical characteristics of magnetic microgels were investigated by TEM, SAXS, XPS and VSM measurements with the focus on the structure--properties relationship. The impact of magnetic microgels loaded with anticancer drug mitoxantrone (MTO) on the non-adherent human T cell leukemia loaded MTO penetrate into cells and both induce apoptosis and later secondary necrosis in a time- and dose dependent manner. In contrast, microgels without MTO are not cytotoxic in the corresponding concentrations. Our results show that MTO-loaded microgels are promising structures for application in magnetic drug targeting.

Authors with CRIS profile

Christina Janko Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Rainer Tietze Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Christoph Alexiou Professur für Nanomedizin

Additional Organisation(s)

Exzellenz-Cluster Engineering of Advanced Materials (EAM)

Involved external institutions

National Institute for Research and Development of Isotopic and Molecular Technologies / Institutul Naţional de Cercetare Dezvoltare pentru Tehnologii Izotopice şi Moleculare (INCDTIM) RO Romania (RO) Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH (HZG) DE Germany (DE) Romanian Academy / Academia Română RO Romania (RO)

How to cite

APA:

Turcu, R., Craciunescu, I., Garamus, V.M., Janko, C., Lyer, S., Tietze, R.,... Vekas, L. (2014). Magnetic microgels for drug targeting applications: Physical--chemical properties and cytotoxicity evaluation. Journal of Magnetism and Magnetic Materials, 380, 307-314. https://doi.org/10.1016/j.jmmm.2014.08.041

MLA:

Turcu, Rodica, et al. "Magnetic microgels for drug targeting applications: Physical--chemical properties and cytotoxicity evaluation." Journal of Magnetism and Magnetic Materials 380 (2014): 307-314.

BibTeX: Download