Sterilization effects on the physical properties and cytotoxicity of poly (glycerol sebacate)

Rai R, Tallawi M, Roether J, Detsch R, Barbani N, Rosellini E, Kaschta J, Schubert DW, Boccaccini AR (2013)

Publication Language: English

Publication Status: Published

Publication Type: Journal article

Publication year: 2013

Journal

Materials Letters Elsevier

Publisher: Elsevier

Book Volume: 105

Pages Range: 32-35

DOI: 10.1016/j.matlet.2013.04.024

Abstract

The influence of conventional sterilization methods such as gamma irradiation, ethylene oxide treatment and steam exposure on the physical properties of poly(glycerol sebacate) (PGS) was investigated. Scanning electron microscope (SEM) observations, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) and Raman spectra demonstrated that the applied sterilization methods do not induce adverse surface modifications. The sterilized samples also maintained their thermal and mechanical properties post-sterilization. In addition, gamma sterilized PGS films did not induce any toxicity when films were in contact with murine fibroblast 313 cells. PGS is compatible for all the sterilization methods used in this study, which is of relevance for the wider application of PGS in medical devices. (C) 2013 Elsevier B.V. All rights reserved.

Authors with CRIS profile

Ranjana Rai Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Marwa Tallawi Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) (LSP) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Joachim Kaschta Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) (LSP) Dirk Schubert Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) (LSP) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

University of Pisa / Università di Pisa (UniPi) IT Italy (IT)

How to cite

APA:

Rai, R., Tallawi, M., Roether, J., Detsch, R., Barbani, N., Rosellini, E.,... Boccaccini, A.R. (2013). Sterilization effects on the physical properties and cytotoxicity of poly (glycerol sebacate). Materials Letters, 105, 32-35. https://doi.org/10.1016/j.matlet.2013.04.024

MLA:

Rai, Ranjana, et al. "Sterilization effects on the physical properties and cytotoxicity of poly (glycerol sebacate)." Materials Letters 105 (2013): 32-35.

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