Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor
Ohayon D, Garces A, Joly W, Soukkarieh C, Takagi T, Sabourin JC, Agius E, Darling DS, Barbara PDS, Higashi Y, Stolt C, Hugnot JP, Richardson WD, Carroll P, Pattyn A (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 17
Pages Range: 1473-1481
Journal Issue: 6
DOI: 10.1016/j.celrep.2016.10.016
Abstract
During spinal cord development, astrocyte precursors arise from neuroepithelial progenitors, delaminate from the ventricular zone, and migrate toward their final locations where they differentiate. Although the mechanisms underlying their early specification and late differentiation are being deciphered, less is known about the temporal control of their migration. Here, we show that the epithelial-mesenchymal transition regulator Zeb1 is expressed in glial precursors and report that loss of Zeb1 function specifically delays the onset of astrocyte precursor delamination from the ventricular zone, correlating with transient deregulation of the adhesion protein Cadherin-1. Consequently, astrocyte precursor invasion into the Zeb1(-/-) mutant white matter is delayed, and induction of their differentiation is postponed. These findings illustrate how fine regulation of adhesive properties influences the onset of neural precursor migration and further support the notion that duration of exposure of migrating astrocyte precursors to environmental cues and/or their correct positioning influence the timing of their differentiation.
Authors with CRIS profile
Involved external institutions
National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM)
France (FR)
Aichi Human Service Center
Japan (JP)
Université Fédérale de Toulouse Midi-Pyrénées
France (FR)
University of Louisville (UofL)
United States (USA) (US)
University of Montpellier / Université Montpellier
France (FR)
University College London (UCL)
United Kingdom (GB)
France (FR)
Aichi Human Service Center
Japan (JP)
Université Fédérale de Toulouse Midi-Pyrénées
France (FR)
University of Louisville (UofL)
United States (USA) (US)
University of Montpellier / Université Montpellier
France (FR)
University College London (UCL)
United Kingdom (GB)
How to cite
APA:
Ohayon, D., Garces, A., Joly, W., Soukkarieh, C., Takagi, T., Sabourin, J.-C.,... Pattyn, A. (2016). Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor. Cell Reports, 17(6), 1473-1481. https://doi.org/10.1016/j.celrep.2016.10.016
MLA:
Ohayon, David, et al. "Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor." Cell Reports 17.6 (2016): 1473-1481.
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