Gmeiner P (2007)
Publication Type: Journal article
Publication year: 2007
Publisher: Elsevier
Book Volume: 1768
Pages Range: 871-887
DOI: 10.1016/j.bbamem.2006.12.001
Various pharmacological studies have implicated the dopamine D3 receptor as an interesting therapeutic target in the treatment of different neurological disorders. Because of these putative therapeutic applications, D3 receptor ligands with diverse intrinsic activities have been an active field of research in recent years. Separation of purely D3-mediated drug effects from effects produced by interactions with similar biogenic amine receptors allows to verify the therapeutic impact of D3 receptors and to reduce possible side-effects caused by "promiscuous" receptor interactions. The requirement to gain control of receptor selectivity and in particular subtype selectivity has been a challenging task in rational drug discovery for quite a few years. In this review, recently developed structural classes of D3 ligands are discussed, which cover a broad spectrum of intrinsic activities and show interesting selectivities. © 2006 Elsevier B.V. All rights reserved.
APA:
Gmeiner, P. (2007). Dopamine D3 Receptor Ligands - Recent Advances in the Control of Subtype Selectivity and Intrinsic Activity. Biochimica Et Biophysica Acta-Biomembranes, 1768, 871-887. https://doi.org/10.1016/j.bbamem.2006.12.001
MLA:
Gmeiner, Peter. "Dopamine D3 Receptor Ligands - Recent Advances in the Control of Subtype Selectivity and Intrinsic Activity." Biochimica Et Biophysica Acta-Biomembranes 1768 (2007): 871-887.
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