Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics

Konnerth CG, Braig V, Schmidt J, Lee G, Peukert W, Ito A (2017)

Publication Language: English

Publication Type: Journal article

Publication year: 2017

Journal

Chemie Ingenieur Technik Wiley-VCH Verlag

Publisher: Wiley-VCH Verlag

Book Volume: 89

Pages Range: 1060-1071

Journal Issue: 89

DOI: 10.1002/cite.201600190

Abstract

An industrially feasible formulation approach combining media milling and spray-drying was applied to improve dissolu-

tion characteristics of the poorly soluble drug mefenamic acid (MA). The approach was studied for two MA polymorphs

at different stressing and pH conditions. It was found that final MA product particle sizes are rather determined by the

solid-liquid equilibrium than by mechanical fracture. Obtained drug particles are only composed of the most stable poly-

morph. Direct compressed tablets containing MA nanocrystals exhibit a significant improvement of in vitro dissolution

kinetics as compared to tablets with micronized drug particles.

Authors with CRIS profile

Christoph-Günther Konnerth Lehrstuhl für Interfaces und Partikeltechnologie (LFG) Veronika Braig Lehrstuhl für Pharmazeutische Technologie und Biopharmazie Jochen Schmidt Lehrstuhl für Interfaces und Partikeltechnologie (LFG) Geoffrey Lee Lehrstuhl für Pharmazeutische Technologie und Biopharmazie Wolfgang Peukert Lehrstuhl für Interfaces und Partikeltechnologie (LFG)

Additional Organisation(s)

Exzellenz-Cluster Engineering of Advanced Materials (EAM)

How to cite

APA:

Konnerth, C.-G., Braig, V., Schmidt, J., Lee, G., Peukert, W., & Ito, A. (2017). Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics. Chemie Ingenieur Technik, 89(89), 1060-1071. https://doi.org/10.1002/cite.201600190

MLA:

Konnerth, Christoph-Günther, et al. "Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics." Chemie Ingenieur Technik 89.89 (2017): 1060-1071.

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