P200: Role of the ATP-citrate lyase (ACLY) in the formation of antibody-secreting cells
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.08.2026
End date : 31.07.2027
Project details
Scientific Abstract
B cell activation and differentiation into antibody-secreting cells (ASC) is crucial for immunity against pathogens or vaccines. ASC formation involves major changes in morphology and metabolism. We will investigate how lipogenesis, and specifically the ATP citrate lyase (ACLY), controls this process in a B cell-specific knockout model. We will analyze the ACLY function during germinal center formation and during antigen-specific humoral responses in vivo, as well as metabolic activity in vitro.
